Welcome to TH lab

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Research

The synthesis of proteins using genetic information is a fundamental process in all life forms. In higher organisms, the process is tightly controlled and much of this regulation occurs during the initial steps of translation. Translational control plays an important role in many key life processes, including early embryonic development, learning and memory, and the response to cellular stress. Although translation initiation is a fundamental and indispensable process, many of its aspects are poorly understood. TH lab employs biochemical, mutational, and structural biology approaches to understand the molecular details of the initial steps of protein synthesis and to figure out how it is regulated. Understanding translation initiation and its regulation will be beneficial for many human disorders and cancers. In addition, it may provide avenues for the development of strategies for modulation of translation initiation and development of novel therapeutic strategies against bacterial, fungal, and viral infection.

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Published Work

  1. Mishra RK, Datey A, Hussain T. mRNA recruiting eIF4 factors involved in protein synthesis and its regulation. Biochemistry (2020): 59, 34-46. doi: 10.1021/acs.biochem.9b00788

  2. Poornima G, Mythili R, Nag P, Parbin S, Verma PK, Hussain T. and Rajyaguru PI. RGG-motif self-association regulates eIF4G-binding translation repressor protein Scd6. RNA Biol. (2019):16(9):1215-1227. doi: 10.1080/15476286.2019.1621623

  3. Llácer JL*, Hussain T*, Saini AK*, Nanda J*, Kaur S, Gordiyenko Y, Kumar R, Hinnebusch AG, Lorsch JR and Ramakrishnan V. Translational initiation factor eIF5 replaces eIF1 on the 40S ribosomal subunit to promote start-codon recognition. eLife (2018) 7:e39273.  

  4. Hussain T*, Llacer JL*, Wimberly B*, Jeffrey S. Kieft and Ramakrishnan V. Large-Scale Movements of IF3 and tRNA during Bacterial Translation Initiation. Cell (2016) 167: 133-144.

  5. Llacer JL*, Hussain T*, Marler L, Aitken CE, Thakur A, Lorsch JR, Hinnebusch AG and Ramakrishnan V. Conformational differences between open and closed states of the eukaryotic translation initiation complex. Mol Cell (2015) 59: 399-412.

  6. Ahmad S, Muthukumar S, Kuncha SK, Routh SB, Yerabham AS, Hussain T, Kamarthapu V, Kruparani SP and Sankaranarayanan R. Specificity and catalysis hardwired at the RNA-protein interface in a translational proofreading enzyme; Nat Commun. (2015) Jun 26;6:7552. doi: 10.1038/ncomms8552.

  7. Hussain T*, Llacer JL*, Fernandez IS, Munoz A, Martin-Marcos P, Savva CG, Lorsch JR, Hinnebusch AG and Ramakrishnan V. Structural changes enable start codon recognition by the eukaryotic translation initiation complex; Cell (2014) 159: 597-607.

  8. Amunts A*, Brown A*, Bai XC*, Llácer JL*, Hussain T, Emsley P, Long F, Murshudov G, Scheres SH and Ramakrishnan V. Structure of the yeast mitochondrial large ribosomal subunit; Science (2014) 343(6178): 1485-1489.

  9. Ahmad S*, Routh SB*, Kamarthapu V, Chalissery S, Sowndarya M, Hussain T, Krupani SP, Deshmukh MV, Sankaranarayanan R. Mechanism of chiral proofreading during translation of the genetic code; Elife (2013) 2: e01519.

  10. Fernández IS*, Bai XC*, Hussain T, Kelley AC, Lorsch JR, Ramakrishnan V, Scheres SH. Molecular architecture of a eukaryotic translational initiation complex; Science. (2013) 342(6160): 1240585.

  11. Matharu NK, Hussain T, Sankaranarayanan R, Mishra RK. Vertebrate homologue of Drosophila GAGA factor; J. Mol. Biol. (2010)400, 434-447.

  12. Hussain T, Kamarthapu V, Kruparani SP, Deshmukh MV, Sankaranarayanan R. Mechanistic insights into cognate substrate discrimination during proofreading in translation; Proc Natl Acad Sci USA (2010) 107, 22117–22121.

  13. Hussain T*, Kruparani SP*, Pal B, Dock-Bregeon AC, Dwivedi S, Shekar MR, Sureshbabu K, Sankaranarayanan R. Post-transfer editing mechanism of a D-aminoacyl-tRNA deacylase-like domain in threonyl-tRNA synthetase from archaea; EMBO J. (2006) 25, 4152–4162.

  14. * Equal Contribution

 

Our Team

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 Tanweer Hussain

Prinicipal Investigator

Postdoctoral research - MRC Laboratory of Molecular Biology, Cambridge, UK

Ph.D - Centre for Cellular and Molecular Biology, Hyderabad, INDIA

AWARDS

DBT/Wellcome Trust India Alliance Intermediate Fellowship

INSA (Indian National Science

Academy) Young Scientist Medal 2012
EMBO (European Molecular Biology Organization) Long Term Fellowship 2011
Career Development Fellowship, 2011 by MRC Laboratory of Molecular Biology, Cambridge, UK 
First Prize in Eli Lilly and Company Asia Outstanding Thesis Award, 2011
David Blow Scholarship  2009 by CCP4 UK 
Ranbaxy Science Foundation Young Scientist Award, Medical Sciences, 2006-07 
Dr. K. V. Rao Annual Research Award, Biological Sciences, 2006-07



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 Faisal Khaja Tarique

Post doctoral fellow 
Year of joining TH lab: 2019

B.Sc. - Patna University
M.Sc. - Guru Nanak University
Ph.D. - J.N.U
Post Doc - J.N.U
Post Doc - Rutgers University

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Mohammad Afsar

Post-Doctoral Fellow
Year of joining TH lab: 2020

B.Sc., (Hons) (2008-2011) Biochemistry, Department of Biochemistry, A.M.U. Aligarh, India
M.Sc., (2011-2013) Biochemistry, Department of Biochemistry, A.M.U. Aligarh, India.
Ph.D: (2015-2020) CSIR-CDRI Lucknow

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Bijaylaxmi Parida

Ph.D student
Year of joining TH lab: 2017

B.Sc. - Utkal University
M.Sc. - Ravenshaw University
M.Phil. - Utkal University

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Ayushi Datey

Ph.D student
Year of joining TH lab: 2017

B.Sc. - Nagpur University
M.Sc. - MSU Baroda

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Rishi Kumar Mishra

Int-Ph.D student 
Year of joining TH lab: 2017

B.Sc. - Banaras Hindu University
M.Sc. - Indian Institute of Science

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Deepakash Das

Ph.D student 
Year of joining TH lab: 2019

B.Sc in Microbiology (honours) 
Scottish Church College, University of Calcutta (2014 - 17)

M.Sc in Biotechnology
Savitribai Phule Pune University (2017 - 19)

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Prafful Sharma

Ph.D student
Year of joining TH lab: 2019

B.Sc. Microbiology,
M.J college, KBC North Maharashtra University Jalgaon (2014-17)
M.Sc Microbiology.
Savitribai Phule Pune University (2017-19)

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Darshan Yadav

Integrated Ph.D. student
Year of joining TH lab: 2020

BSc: Biotechnology (Ram Niranjan Jhunjhunwala College University of Mumbai) (2017-2019)
MS: Indian Institute of Sciences (2019-2021)

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Vivek Singh Pal

Ph.D student
Year of joining TH lab: 2020

BSc - Botany (hons.) Year 2015-18, Bananas Hindu University. 
MSc - Botany,  Year 2018-2020, Bananas Hindu University

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Adwaith B Uday

Year of joining TH lab: 2019

UG student, IISc Bangalore

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Rohit Marakkath Sunil

Year of joining TH lab: 2019

UG student, IISc Bangalore

 

Alumni

Post-Docs

1. Dr Thyageshwar Chandran, (Present: Assistant Professor NIT Warangal, India)
2. Jyoti Gupta

Project Assistants

1. Agnismita Mondal

2. Priyabrata Nag

3. Huma Rahil

Dissertation trainees and interns

1.

 

Upcoming Events

  • Event
    17-Mar-2025, 5:00 pm
    San Francisco, CA, USA
    Join Us
 

Contact Us

Tanweer Hussain, Assistant Professor, MRDG
IISc Bangalore 560012

+91 (0) 80-2293-3262