Peer-reviewed Research publications (from IISc):

1.Singh J*, Mishra RK*, Shreya AA, Hussain T#, Varshney U#  The initiation factor 3 (IF3) residues interacting with initiator tRNA elbow modulate the fidelity of translation initiation and growth fitness in Escherichia coli. (2022) Nucleic Acids Res. https://doi.org/10.1093/nar/gkac1053

2. Basu I, Gorai B, Chandran T, Maiti PK# and Hussain T,# Selection of start codon during mRNA scanning in eukaryotic translation initiation Commun Biol 5, 587 (2022); doi.org/10.1038/s42003-022-03534-2

3.  M Afsar, R Narayan, MN Akhtar, Das D, H Rahil, Nagaraj SK, SM Eswarappa, S Tripathi, Hussain T#. Drug targeting Nsp1-ribosomal complex shows antiviral activity against SARS-CoV-2. eLife (2022);11:e74877 doi: 10.7554/eLife.74877

4. Llácer JL*#, Hussain T*#, Dong J*, Villamayor L, Gordiyenko Y, Hinnebusch AG# (2021) Large-scale movement of eIF3 domains during translation initiation modulate start codon selection. Nucleic Acids Res. (2021) Oct 14:gkab908. doi: 10.1093/nar/gkab908. Online ahead of print.

5. Kumar R, Afsar M, Khandelwal N, Chander Y, Riyesh T, Dedar RK, Gulati BR, Pal Y, Barua S, Tripathi BN#, Hussain T#, Kumar N#. Emetine suppresses SARS-CoV-2 replication by inhibiting interaction of viral mRNA with eIF4E. Antiviral Res. (2021):189,105056. doi: 10.1016/j.antiviral.2021.105056.

6. Datta M, Pillai M, Modak MJ, Liiv A, Khaja FT, Hussain T, Remme J, Varshney U. A mutation in the ribosomal protein uS12 reveals novel functions of its universally conserved PNSA loop. Mol Microbiol. (2020): doi: 10.1111/mmi.14675.

7. Mishra RK, Datey A, Hussain T#. mRNA recruiting eIF4 factors involved in protein synthesis and its regulation. Biochemistry (2020): 59, 34-46. doi: 10.1021/acs.biochem.9b00788.

8. Poornima G, Mythili R, Nag P, Parbin S, Verma PK, Hussain T. and Rajyaguru PI. RGG-motif self-association regulates eIF4G-binding translation repressor protein Scd6. RNA Biol. (2019):16(9):1215-1227. doi: 10.1080/15476286.2019.1621623.

9. Llácer JL*, Hussain T*, Saini AK*, Nanda J*, Kaur S, Gordiyenko Y, Kumar R, Hinnebusch AG, Lorsch JR, and Ramakrishnan V. Translational initiation factor eIF5 replaces eIF1 on the 40S ribosomal subunit to promote start-codon recognition. eLife (2018): 7:e39273.

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Other publications (Editorial):

 

1. Dutta, S.#, Hussain, T.# Editorial. J Indian Inst Sci 98, 229–230 (2018). https://doi.org/10.1007/s41745-018-0089-x

( #Corresponding Author * Equal Contribution)

 

 

Peer-reviewed Research publications (At the time of joining IISc)

8. Hussain T*, Llacer JL*, Wimberly B*, Jeffrey S. Kieft and Ramakrishnan V. Large-Scale Movements of IF3 and tRNA during Bacterial Translation Initiation. Cell (2016) 167: 133-144.

9. Llacer JL*, Hussain T*, Marler L, Aitken CE, Thakur A, Lorsch JR, Hinnebusch AG and Ramakrishnan V. Conformational differences between open and closed states of the eukaryotic translation initiation complex. Mol Cell (2015) 59: 399-412.

10. Ahmad S, Muthukumar S, Kuncha SK, Routh SB, Yerabham AS, Hussain T, Kamarthapu V, Kruparani SP, Sankaranarayanan R. Specificity and catalysis hardwired at the RNA-protein interface in a translational proofreading enzyme; Nat Commun. (2015) Jun 26;6:7552. doi: 10.1038/ncomms8552.

11. Hussain T*, Llacer JL*, Fernandez IS, Munoz A, Martin-Marcos P, Savva CG, Lorsch JR, Hinnebusch AG and Ramakrishnan V. Structural changes enable start codon recognition by the eukaryotic translation initiation complex; Cell (2014) 159: 597-607.

12. Amunts A*, Brown A*, Bai XC*, Llácer JL*, Hussain T, Emsley P, Long F, Murshudov G, Scheres SH, Ramakrishnan V. Structure of the yeast mitochondrial large ribosomal subunit; Science (2014) 343(6178): 1485-1489.

13. Ahmad S*, Routh SB*, Kamarthapu V, Chalissery S, Sowndarya M, Hussain T, Krupani SP, Deshmukh MV, Sankaranarayanan R. Mechanism of chiral proofreading during translation of the genetic code; eLife (2013) 2: e01519.

14. Fernández IS*, Bai XC*, Hussain T, Kelley AC, Lorsch JR, Ramakrishnan V, Scheres SH. Molecular architecture of a eukaryotic translational initiation complex; Science. (2013) 342(6160): 1240585.

15. Matharu NK, Hussain T, Sankaranarayanan R, Mishra RK. Vertebrate homologue of Drosophila GAGA factor; J. Mol. Biol. (2010) 400, 434-447.

16. Hussain T, Kamarthapu V, Kruparani SP, Deshmukh MV, Sankaranarayanan R. Mechanistic insights into cognate substrate discrimination during proofreading in translation; Proc Natl Acad Sci USA (2010) 107, 22117–22121.

17. Hussain T*, Kruparani SP*, Pal B, Dock-Bregeon AC, Dwivedi S, Shekar MR, Sureshbabu K, Sankaranarayanan R. Post-transfer editing mechanism of a D-aminoacyl-tRNA deacylase-like domain in threonyl-tRNA synthetase from archaea; EMBO J. (2006) 25, 4152–4162.(* Equal Contribution)